Buy FOXO4-DRI Peptide

FOXO4-DRI is a special type of peptide. It helps break the link between FOXO4 and p53. This action can remove old and unhealthy cells called senescent cells. When these cells die, it may help refresh tissues and lower diseases linked to aging. Researchers mainly study this peptide to understand its effects on aging and cell health.

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FOXO4-DRI Peptide Vial 10mg
£198.36 – £207.34 Select options This product has multiple variants. The options may be chosen on the product page
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FOXO4-DRI Nasal Spray
£206.36 – £407.72 Select options This product has multiple variants. The options may be chosen on the product page
Twin Pack Saver

FOXO4-DRI 10mg Pre-Mixed Peptide
£202.13 – £545.75 Select options This product has multiple variants. The options may be chosen on the product page

Which FOXO4-DRI Product is Right for You?

PharmaGrade Store Greece supplies a range of FOXO4-DRI products, including:

FOXO4-DRI Peptide Vial – Lyophilized FOXO4-DRI peptide supplied in a glass vial. Please note you also require bacteriostatic water when reconstituting your peptide.
FOXO4-DRI is available in 10mg vial.
FOXO4-DRI Nasal Spray – an easy to use, pre-mixed spray ready for absorption via the nasal cavity. Choose from 15ml or 30ml nasal sprays here.
FOXO4-DRI Pre-Mixed Peptide Pen – Peptide pen kits and refill cartridges come ready to use pre-mixed with FOXO4-DRI and bacteriostatic water. Buy FOXO4-DRI 10mg Pre-Mixed Pen here.

Buy FOXO4-DRI for Research Purposes

FOXO4-DRI is a unique synthetic peptide. It acts as a senolytic agent in a special way. It interrupts the connection between the FOXO4 protein (forkhead box O 4) and p53. p53 plays a key role in how cells deal with stress.

In healthy cells, FOXO4 binds to p53. This helps older or damaged cells live longer. It prevents p53 from triggering cell death [1]. However, FOXO4-DRI breaks this bond. This lets p53 go free, allowing it to do its job. When p53 is active, it leads to cell death. This process helps get rid of senescent cells [2].

This process aims to remove old cells, known as senescent cells, while keeping healthy ones safe. This helps slow down aging and reduces cell damage. By eliminating these aging cells, FOXO4-DRI could improve tissue health and functions of cells. It might also help delay or reduce diseases related to aging [3].

Greece Researchers are exploring it for anti-aging treatments. These treatments work against the bad effects of cellular senescence, such as inflammation and the decline of organs over time.

FOXO4-DRI Peptide Benefits

Previous Greece studies have suggested that FOXO4-DRI may have the following benefits:

Selective Removal of Senescent Cells – FOXO4-DRI specifically targets and removes senescent cells by disrupting the FOXO4-p53 interaction, inducing apoptosis in these aged or damaged cells without harming healthy ones [3].
FOXO4-DRI enhanced tissue rejuvenation – By clearing out senescent cells, FOXO4-DRI can cause a significant increase in the regeneration of tissues and may restore their functionality, making it a promising agent for reversing cellular aging effects [4].
Improved cellular function – The removal of dysfunctional senescent cells allows healthy cells to perform better, improving overall tissue maintenance and repair processes [4].
FOXO4-DRI may reduce age related inflammation – Senescent cells often release pro-inflammatory factors known as the senescence-associated secretory phenotype (SASP). By eliminating these cells, FOXO4-DRI helps to reduce chronic inflammation associated with aging, including articular cartilage [5].

Clinical Research FOXO4-DRI Greece

FOXO4-DRI peptide is a key focus in studies about aging and healing. It can focus on senescent cells. This peptide was first made as a senolytic agent. It works by blocking the link between FOXO4 and p53. This action causes the bad cells to die while keeping the good cells safe [1].

Early research, mostly done on different groups of older mice, found that FOXO4-DRI can help heal tissues, make organs work better, and reduce inflammation related to aging [6]. These studies showed that the peptide can reduce the bad effects of something known as the senescence-associated secretory phenotype (SASP). SASP leads to long-lasting inflammation and harm to tissues.

Current research is still trying to find out how it can help with age-related diseases like osteoarthritis and brain diseases [6]. However, there are still some challenges. We need to learn how safe it is over a long time and understand the specific biological pathways that are involved.

Specifications of FOXO4-DRI Greece

View PharmaGrade Store FOXO4-DRI Greece HPLC Certificate here.

Amino Acids Sequence: H-LTLRKEPASEIAQSIL EAYSQNGWANRRSGGK RPPPRRRQRRKRG-OH

Molecular Formula:C228H388N86O64

Molecular Weight: 5358.05 g/mol

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Frequently Asked Questions about FOXO4-DRI Peptide Greece

What are senescent cells?

Senescent cells are old or damaged cells. They stop dividing and cannot grow anymore. This occurs naturally due to several reasons. These reasons include DNA damage, oxidative stress, or the shortening of telomeres. While these cells remain active metabolically, they do not support healing or tissue growth.

Senescent cells can play a role in cancer prevention. They help stop damaged cells from dividing too much. However, over time, the number of senescent cells can also be harmful. A major issue is that they let out substances that cause inflammation. This is called the cell senescence associated secretory phenotype (SASP factors). This release results in long-term inflammation, issues with tissues, articular cartilage injuries and age-related diseases. Some of these diseases are osteoarthritis, fibrosis, and heart problems.

Recent Greece studies have examined how to treat senescent cells using therapies like the FOXO4-DRI peptide. This treatment is designed to eliminate unhealthy cells. By removing them, scientists aim to make tissues feel younger, reduce inflammation, and slow down aging. These findings show promise for new methods to combat aging and improve health as we grow older.

How can FOXO4-DRI help knee joints?

FOXO4-DRI is a senolytic peptide that has shown potential in treating knee joint issues by targeting and removing senescent cells. These cells accumulate with age and contribute to various age-related diseases, including those affecting the joints. Greece Research indicates that FOXO4-DRI can selectively remove senescent cells in chondrocytes, which are the cells found in cartilage. This removal can have a significant difference in the function of these cells and potentially restore cartilage health, thereby improving joint function and reducing leg pain [1].

Are there any adverse effects associated with FOXO4-DRI?

The potential side effects of the FOXO4-DRI peptide include treatment-emergent adverse events such as upper respiratory infections, bronchitis, and gastrointestinal issues like nausea and diarrhoea. Additionally, while FOXO4-DRI has been shown to limit chemotoxicity in certain contexts, its overall safety profile in humans requires further research to fully understand all potential side effects.

Blogs:

FOXO4-DRI Peptide on Hair Growth

This blog explores the potential of FOXO4-DRI peptide in promoting hair growth. It highlights the peptide’s ability to target senescent cells, which are known to disrupt hair follicle function. By clearing these cells, FOXO4-DRI rejuvenates hair follicles, potentially increasing hair density and thickness. The blog also covers the peptide’s mechanism of action, which involves inhibiting FOXO4 to prevent apoptosis in hair stem cells, thus fostering a healthier environment for hair growth.

Read about hair growth here.

Exploring the Top Peptides for Anti-Aging Skincare

We take a look at the top peptides for anti-aging skincare, highlighting their benefits in enhancing skin elasticity, reducing wrinkles, and improving overall skin health. It discusses key peptides like GHK-Cu, Epitalon, P21, FOXO4-DRI, and NAD+, emphasizing their roles in boosting collagen production, increasing hydration, and protecting against oxidative stress. The blog also addresses considerations such as potential side effects and the importance of selecting the right peptide formulations.

Discover Anti-aging peptides

Scientific Research:

[1] Lei Zhang, Louise E. Pitcher, Vaishali Prahalad, Laura J. Niedernhofer, Paul D. Robbins, Recent advances in the discovery of senolytics, Mechanisms of Ageing and Development, Volume 200, 2021, 111587.

[2] Bourgeois B, Madl T. Regulation of cellular senescence via the FOXO4-p53 axis. FEBS Lett. 2018 Jun;592(12):2083-2097.

[3] Zhang C, Xie Y, Chen H, Lv L, Yao J, Zhang M, Xia K, Feng X, Li Y, Liang X, Sun X, Deng C, Liu G. FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice. Aging (Albany NY). 2020 Jan 20;12(2):1272-1284.

[4] Baar MP, Brandt RMC, Putavet DA, Klein JDD, Derks KWJ, Bourgeois BRM, Stryeck S, Rijksen Y, van Willigenburg H, Feijtel DA, van der Pluijm I, Essers J, van Cappellen WA, van IJcken WF, Houtsmuller AB, Pothof J, de Bruin RWF, Madl T, Hoeijmakers JHJ, Campisi J, de Keizer PLJ. Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging. Cell. 2017 Mar 23;169(1):132-147.e16.

[5] Yanqing Li, Chi Zhang, Haicheng Cheng, LinYan Lv, Xinning Zhu, Menghui Ma, Zhenhan Xu, Junxian He, Yun Xie, Xing Yang, Xiaoyan Liang, Chunhua Deng, Guihua Liu, FOXO4-DRI improves spermatogenesis in aged mice through reducing senescence-associated secretory phenotype secretion from Leydig cells, Experimental Gerontology, Volume 195, 2024, 112522.

[6] Riessland M, Orr ME. Translating the Biology of Aging into New Therapeutics for Alzheimer’s Disease: Senolytics. J Prev Alzheimers Dis. 2023;10(4):633-646.

[7] Huang Y, He Y, Makarcyzk MJ, Lin H. Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes. Front Bioeng Biotechnol. 2021 Apr 29;9:677576.

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